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Vascanox HP

Next-generation nitric oxide support. Vascanox HP targets multiple pathways to support the natural production, storage, and release of nitric oxide.*

Vascanox HP® is a breakthrough product providing nitric oxide support for up to 24 hours with a single dose.*† Vascanox HP supports the natural production, storage, and release of nitric oxide.* Each 60-capsule bottle is a 1-month supply at recommended dosing levels.

As measured by saliva NO test strips in an open label published study.

Suggested Retail $79.00
Your Price $$59.00
Discount courtesy of Elizabeth Yurth, MD
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The Effects

The physiological importance of nitric oxide was established by Nobel-prize winning research.

Human blood under a microscope

The physiological importance of nitric oxide was established in the 1990s and has since been confirmed by scientific studies and clinical experience.

In an open label published study, a single dose of Vascanox HP increased salivary nitric oxide levels for up to 24 hours.*†

Optimal nitric oxide levels have been shown to:

  • Support a healthy cardiovascular system*
  • Support and maintain blood pressure in the normal range*
  • Support healthy circulation*

Calroy’s proprietary, patent-pending formula targets nitric oxide metabolism, using multiple pathways.


As measured by saliva NO test strips in an open label published study.

The Science

Diagram of circulatory system

Nitric oxide is a messenger molecule that is produced in the body through both nitric oxide synthase (NOS) pathway and nitrate-nitrite-nitric oxide pathway. Vascanox HP supports the entire biotransformation cycle for nitric oxide, including both pathways.*

Nitric Oxide Synthase Pathway

Nitric oxide synthases are a group of 3 enzymes catalyzing production of nitric oxide in the body. Endothelial NOS (eNOS) is primarily responsible for the generation of nitric oxide in the vascular endothelium. The mechanical force of blood flow triggers a response in the endothelial glycocalyx, which in turn signals the endothelium to generate nitric oxide.

Vascanox HP bottle

Nitrate -> Nitrite -> Nitric Oxide Pathway

This pathway starts when inorganic nitrate, such as dietary nitrate in green leafy vegetables is ingested and absorbed into the circulation. Circulating nitrate is transported into the saliva gland and concentrated in the saliva. If secreted in the mouth, nitrate in the saliva is reduced to nitrite by nitrate reducing bacteria. Once swallowed, part of the nitrite is chemically reduced to nitric oxide in the stomach and the rest can be reduced to nitric oxide by several different enzymes after being absorbed.

The Research

We are committed to products that change lives.

Calroy is committed to the creation of science-based dietary supplements that support foundational health. We conduct clinical and scientific research to study the effects of our products.

See research on this novel nitric oxide supplement

Explore Research

The Ingredients

Thoughtfully Sourced, Quality Controlled, Vegan

Vascanox HP contains a carefully curated selection of synergistic compounds derived from fruits and vegetables. In addition to potassium nitrate, a precursor for nitric oxide, a blend with polyphenols and antioxidant activities supports the entire biotransformation process for nitric oxide.

The product is assembled using a Total Quality System, which includes strict compliance with cGMP’s current good manufacturing practices as defined by the United States Food and Drug Administration.

Batch and test records are maintained throughout the manufacturing process to ensure the guaranteed quality of the final product.

As measured by saliva NO test strips in an open label published study.



Find answers to commonly asked questions in our FAQs.

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